Fasting Required: No Specimen: Blood Results: 3-5 Business Days> Description: Progesterone balances and offsets the powerful effects of estrogen. An imbalance between progesterone and estrogen can cause weight gain, insomnia, anxiety, depression, migraines, and even more debilitating conditions such as cancer, uterine fibroids, ovarian cysts, and osteoporosis in women. In men, the imbalance can cause weight gain, loss of libido and prostate enlargement. Methodology: Immunoassay (IA) Limitations: Heterophil antibodies may produce falsely-elevated results. Clinical Significance: Levels increase sharply during the luteal phase of the menstrual cycle. The level increases from 9 to 32 weeks of pregnancy.