Fasting Required: No Specimen: Blood Results: 3-5 Business Days Description: Progesterone balances and offsets the powerful effects of estrogen. An imbalance between progesterone and estrogen can cause weight gain, insomnia, anxiety, depression, migraines, and even more debilitating conditions such as cancer, uterine fibroids, ovarian cysts, and osteoporosis in women. In men, the imbalance can cause weight gain, loss of libido and prostate enlargement.